Physiologic Pulsatile Pump (PPP) Bypass, Assist, ECMO Pediatric/Small Animal Model Potential to Dramatically Improve Outcomes ♦Trends/Limitations ♦PPP Story ♦Published Studies Medical Engineering Company LLC www.medicalengineeringco.com Tani Tatum, President & CEO Contact: Stephen Walker, Director of Operations stephenwalker08@aol.com · 702 301-7429 Cardiothoracic:
Bypass, Assist, ECMO Current
Problems and Trends – Published Data Bypass ♦ “Organ injury (brain, heart, kidneys) is
still a significant problem among 10 – 30% of postoperative pediatric heart
patients. Poor
tissue perfusion and the mode of perfusion (pulsatile vs. non-pulsatile) are
major factors” ♦ “Roller pumps with pulsatile modules
produce only 12.4% of the power of the human heart – This
is Inadequate pulsatility re:
dt/dt, ejection time, pulse pressure, and stroke volume” ♦ Microcirculation: Non-physiologic flow does not maintain capillary bed
patency ♦ Hemodilution – High priming volumes ♦ Blood Damage – Hemolysis Ventricular
Assist – NHLBI Limitations and other published data ♦ Large device size ♦ Limited physiological controls for prolonged use ♦ Uncertainty about long-term non-pulsatile flow ♦ Multiple organ failures ♦ Pulmonary edema and hypertension ECMO ♦ Major CNS injury – Up to 30% ♦ Multi-organ failures ♦ Hemodilution ♦ Blood damage (hemolysis) Solutions: The PPP solves
all the above current problems -Organ Blood Flow: The PPP is the only system that
provides full flow with normal oxygenation to all the major vital organs and
the microcirculation -Hemodynamic Power: The PPP produces 100% of the power
of the heart. Published studies
show enormous differences compared to other pulsatile and non-pulsatile systems
including dramatically improved vital organ recovery -Physiological
Controls Arterial: The PPP is the only system that has
Independent Controls for: Pulse Rate, Stroke Volume, Upstroke
Rise Time – All are essential for accurate pulsatile flow Venous: Independent control over venous
inflow/pressure including physiologic venous wave form -Pulmonary: PPP produces no edema or
hypertension -Priming Volumes: The system was designed for very low
priming volumes. The chambers sit
on the field, and fill passively with positive pressure -Blood
Damage: The delicate tricuspid valves produce no
abnormal hemolysis -Portable: The PPP fits into airplane carry-on
luggage -EKG-Trigger
with Variable Delay: For LVAD, RVAD, BiVAD,
and ECMO PPP Story History The heart surgeon who designed the
system believed that accurate duplication of pulse pressure, flow, and hemodynamic patterns would have Great Flow Advantages to: Major Vital Organs/Regions and the
Microcirculation Historic
Experiment and published comparative studies confirm theory
Typical
Blood Pressure Curves
THREE ESSENTIAL VARIABLES TO DUPLICATE PULSE PRESSURE, FLOW & HEMODYNAMIC PATTERNS ►PULSE RATE
►STROKE VOLUME
►UPSTROKE TIME THE PPP IS THE ONLY SYSTEM WITH ALL THREE INDEPENDENTLY CONTROLLED PPP Unique Features
– Advantages Independent Controls for: Pulse Rate, Stroke Volume, Upstroke Time
The PPP
is the only system with all 3 Independent Variables Tricuspid Valves
Mimics shape and action of native
valve including thin lunulae No abnormal hemolysis
(blood damage) No
regurgitation (backflow)
Hydraulic drive and Y-Connector; One
chamber is pre & one is post-oxygenator No dampening of the pulse wave with an oxgenator
in line! PPP
Advantages - Capillary Blood Flow
Vital Substance
Exchanges for: Cell Viability,
Tissue Oxygenation, Waste Removal |
